![](\"https:\/\/www.agerpres.ro\/agerpres\/imageResize?path=%2Fmedia%2Fimages%2F2017-06%2F06201036-1420993000.jpg&size=6\")
<\/div>\nStudiul, publicat mar\u021bi \u00een “European Heart Journal”, demonstreaz\u0103 \u00een premier\u0103 c\u0103 este posibil\u0103 imunizarea cu o molecul\u0103 care determin\u0103 producerea de anticorpi la \u0219oareci modifica\u021bi genetic \u00eempotriva unei enzime numit\u0103 PCSK9, ce \u00eempiedic\u0103 eliminarea din s\u00e2nge a lipoproteinelor cu densitate sc\u0103zut\u0103 (LDL, supranumit \u0219i colesterol “r\u0103u”).<\/p>\n
Persoanele care au niveluri ridicate de colesterol LDL, fie din cauze genetice, fie ca urmare a alimenta\u021biei nes\u0103n\u0103toase ori a stilului de via\u021b\u0103 necorespunz\u0103tor, manifest\u0103 un risc mai mare de a dezvolta \u00een mod prematur boli cardiovasculare. Aceste afec\u021biuni ale inimii \u0219i vaselor de s\u00e2nge, cauzate de ateroscleroz\u0103, au devenit principala cauz\u0103 de \u00eemboln\u0103vire \u0219i mortalitate \u00een lume dep\u0103\u0219ind ca frecven\u021b\u0103 infec\u021biile.<\/p>\n
\u00cen prezent, pentru sc\u0103derea nivelurilor de colesterol LDL sunt utilizate medicamente precum statinele, \u00eens\u0103 acestea trebuie administrate zilnic \u0219i, de\u0219i sunt bine tolerate de organism, pot cauza efecte adverse la unele persoane.<\/p>\n
Potrivit noii cercet\u0103ri, \u00een cazul \u0219oarecilor care au primit o alimenta\u021bie bogat\u0103 \u00een gr\u0103simi pentru a se induce cre\u0219terea nivelului de colesterol LDL \u0219i apari\u021bia aterosclerozei, vaccinul AT04A a redus cu 53% cantitatea de colesterol din s\u00e2nge \u0219i a mic\u0219orat cu 64% efectele negative produse asupra vaselor de s\u00e2nge, reduc\u00e2ndu-se totodat\u0103 markerii biologici ai inflama\u021biilor de la nivelul acestora cu 21-28%, \u00een compara\u021bie cu \u0219oarecii nevaccina\u021bi, se arat\u0103 \u00een cercetare.<\/p>\n
\u00cen plus, anticorpii stimula\u021bi prin vaccin au fost func\u021bionali pe toat\u0103 perioada studiului, iar concentra\u021biile acestora au r\u0103mas ridicate p\u00e2n\u0103 la finalul cercet\u0103rii.<\/p>\n
Dr. G\u00fcnther Staffler, conduc\u0103torul serviciului de tehnologie de la AFFiRis, compania care a dezvoltat vaccinul AT04A, a declarat c\u0103 acesta “a reu\u0219it s\u0103 produc\u0103 anticorpi care au \u021bintit \u00een mod specific enzima PCSK9 pe toat\u0103 perioada studiului”.<\/p>\n
Ca urmare, nivelurile de colesterol au sc\u0103zut \u00een mod consistent \u0219i pe termen lung, ceea ce a contribuit la reducerea depozitelor de gr\u0103sime din artere, a deterior\u0103rii determinat\u0103 de ateroscleroz\u0103 \u0219i la reducerea inflama\u021biilor pere\u021bilor arterelor, a mai explicat Staffler, unul dintre autorii cercet\u0103rii.<\/p>\n
“\u00cen cazul \u00een care aceste descoperiri se vor aplica \u00een mod favorabil \u0219i \u00een cazul oamenilor, \u0219i \u021bin\u00e2nd cont c\u0103 anticorpii produ\u0219i persist\u0103 timp de c\u00e2teva luni dup\u0103 vaccinare, am putea dezvolta o terapie de lung\u0103 durat\u0103 care, dup\u0103 prima vaccinare, nu are nevoie dec\u00e2t de o re\u00eennoire anual\u0103. Acest lucru ar putea duce la un tratament eficient \u0219i mult mai convenabil pentru pacien\u021bi, dar \u0219i la un grad mai mare de tolerabilitate”, a explicat Staffler.<\/p>\n
Sursa: agerpres.ro<\/p>\n","protected":false},"excerpt":{"rendered":"
Un vaccin realizat \u00een vederea imuniz\u0103rii contra cre\u0219terii nivelului de colesterol “r\u0103u” \u0219i a riscului de \u00eengustare a arterelor cauzat<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":"","jetpack_publicize_message":""},"categories":[80],"tags":[],"class_list":["post-24084","post","type-post","status-publish","format-standard","hentry","category-sanatate"],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p61naM-6gs","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts\/24084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24084"}],"version-history":[{"count":1,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts\/24084\/revisions"}],"predecessor-version":[{"id":24086,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts\/24084\/revisions\/24086"}],"wp:attachment":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24084"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24084"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}