\u00cen lumea \u015ftiin\u0163ei, cercet\u0103torii \u015ftiu de ceva timp c\u0103 multe medicamente orale \u2013 printre care medicamente anti-colesterol precum atorvastatin, lovastatin \u015fi simvastatin \u015fi alte medicamente anti-cancer \u015fi pentru afec\u0163iuni cardiace \u2013 provoac\u0103 probleme grave atunci c\u00e2nd pacien\u0163ii consum\u0103 grepfrut.<\/p>\n\n\n\n
Echipa de cercet\u0103tori care a descoperit aceast\u0103 combina\u0163ie periculoas\u0103 acum 20 ani a publicat de cur\u00e2nd un nou raport \u00een care se arat\u0103 c\u0103 num\u0103rul medicamentelor care provoac\u0103 efecte secundare grave atunci c\u00e2nd pacien\u0163ii consum\u0103 grapefruit<\/em> a crescut de la 17 la 43 \u00eentre 2008 \u015fi 2012, pe m\u0103sur\u0103 ce au fost lansate pe pia\u0163\u0103 noi tratamente. Oamenii de \u015ftiin\u0163\u0103 au publicat un articol \u00een jurnalul \u015ftiin\u0163ific CMAJ<\/a> pentru a solicita cadrelor medicale care prescriu aceste medicamente s\u0103 afle mai multe detalii despre interac\u0163iunile dintre substan\u0163e \u015fi fructul de grapefruit<\/em>.<\/p>\n\n\n\n Ingredientele periculoase din sucul de grapefruit <\/em>sunt un grup de substan\u0163e chimice cunoscute sub numele de furanocumarine, explic\u0103 farmacologul David Bailey de la Institutul de Cercet\u0103ri Medicale Lawson, din Ontario, Canada. Aceste substan\u0163e se mai g\u0103sesc \u015fi \u00een portocalele de Sevilla, \u00een lime \u015fi \u00een pomelo.<\/p>\n\n\n\n Furanocumarinele se ata\u015feaz\u0103 \u2013 \u015fi astfel fac inactiv\u0103 \u2013 de enzima CYP3A4, ce joac\u0103 un rol important \u00een descompunerea anumitor medicamente. Dac\u0103 aceast\u0103 enzim\u0103 este inactivat\u0103, prea multe medicamente vor r\u0103m\u00e2ne \u00een sistemul pacientului pentru timp \u00eendelungat, ceea ce va duce la efecte secundare precum moartea subit\u0103, distrugerea rinichilor, s\u00e2nger\u0103ri gastrointestinale \u015fi alte probleme.<\/p>\n\n\n\n Cercet\u0103torii estimeaz\u0103 c\u0103 peste 85 de medicamente interac\u0163ioneaz\u0103 cu grepfrutul, dintre care 43 \u00eentr-un mod periculos. Consumarea unui singur grapefruit <\/em>sau a doar 200 de mililitri de suc de grapefruit<\/em> ar putea fi suficient pentru a altera \u00eentr-un mod semnificativ concentra\u0163ia medicamentelor din corpul unui pacient. <\/p>\n\n\n\n Oamenii de \u015ftiin\u0163\u0103 nu \u015ftiu c\u00e2\u0163i oameni sunt afecta\u0163i de aceast\u0103 problem\u0103, \u00eens\u0103 afirm\u0103 c\u0103 persoanele cu v\u00e2rste mai mari de 45 de ani prezint\u0103 un risc mai mare, pentru c\u0103 acestea consum\u0103 cea mai mare cantitate de grapefruit <\/em>\u015fi totodat\u0103 lor li se prescrie cel mai mare num\u0103r de medicamente.<\/p>\n\n\n\n \u201eC\u00e2t timp cadrele medicale nu sunt con\u015ftiente c\u0103 efectele secundare pe care le observ\u0103 la pacien\u0163i se datoreaz\u0103 consumului de grapefruit<\/em>, este foarte pu\u0163in probabil ca acestea s\u0103 investigheze problema. Noi credem c\u0103 majoritatea cadrelor medicale \u00eenc\u0103 nu cunosc pe deplin interac\u0163iunea dintre medicamente \u015fi grapefruit<\/em>\u201d, scriu cercet\u0103torii \u00een articolul publicat \u00een jurnalul \u015ftiin\u0163ific.<\/p>\n\n\n\n Sursa:descopera.ro<\/p>\n","protected":false},"excerpt":{"rendered":" \u00cen lumea \u015ftiin\u0163ei, cercet\u0103torii \u015ftiu de ceva timp c\u0103 multe medicamente orale \u2013 printre care medicamente anti-colesterol precum atorvastatin, lovastatin<\/p>\n","protected":false},"author":1,"featured_media":47888,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":"","jetpack_publicize_message":""},"categories":[80],"tags":[],"class_list":["post-47887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sanatate"],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/realitatearutiera.ro\/wp-content\/uploads\/2019\/03\/res_7de57a29a35b1ad3c3f2a113b4c3ba65_full.jpg?fit=1200%2C1200&ssl=1","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p61naM-csn","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts\/47887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=47887"}],"version-history":[{"count":2,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts\/47887\/revisions"}],"predecessor-version":[{"id":47890,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/posts\/47887\/revisions\/47890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=\/wp\/v2\/media\/47888"}],"wp:attachment":[{"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=47887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/realitatearutiera.ro\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=47887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}